The new version privacyIDEA 2.20 was just released. It is available via the Ubuntu Launchpad Repositories for 14.04LTS and 16.04LTS and via the python package index. You can read more about it at NetKnights.
You can use nginx to act as a reverse proxy in front of any web application. Kenneth Cummings gave a talk at the ownCloud Conference 2017 how to combine different components to setup such a 2FA reverse proxy. Watch this video on YouTube.